Quick Details:
99% Legit Sarm Powder Sr9011 CAS 1379686-29-9
| Product Name | SR9011 |
| Chemical Name | SR9011 |
| CAS Number | 1379686-29-9 |
| EINECS Number | 212-729-3 |
| Molecular Formula | C14H12F6N2O |
| Molecular Weight | 338.2482992 |
| Molecular Structure | |
| Assay | 99.5% |
| Appearance | White powder |
what is SR9011?
SR9011 is a trifunctional methacrylate monomer that provides exceptional adhesion to metal substrates. Recommended for use in peroxide cured coatings, sealants, and PCV-based plastisols. Performance properties include: good adhesion, good chemical resistance, good hardness, good heat resistance and high abrasion resistance.
Biological Activity:
SR9011 is a potent and specific synthetic REV-ERB agonist that binds to REV-ERB-α with an EC50 ~790 nM and REV-ERB-β with EC50 ~560 nM. It also has good in vivo plasma/brain exposure. The nuclear receptors REV-ERB-α and REV-ERB-β play an integral role in regulating the expression of core clock proteins, driving meters in activity and metabolism.
Administration of SR9011 alters circadian behavior and the circadian pattern of core clock gene expression in the hypothalami of mice. The circadian expression pattern of an array of metabolic genes in the liver, skeletal muscle and adipose tissue was also altered, resulting in increased energy expenditure. Treatment of diet-induced obese mice with SR9011 decreased obesity by reducing fat mass and markedly improved dyslipidaemia and hyperglycaemia. These results indicate that synthetic REV-ERB ligands that pharmacologically target the circadian meter may be beneficial in the treatment of sleep disorders as well as metabolic diseases.
How to Use:
In vitro: SR9011 was used at 5-10 µM concentration in vitro and in cellular assays.
In vivo: IP administration of SR9011 was used at 100 mg/kg once or twice per day for 12-30 days in different mouse models.
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