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AZD-9291(Osimertinib) for Lung Cancer CAS: 1421373-65-0

Item No.: 1421373-65-0
Model NO.: 1421373-65-0
Customized: Customized
Suitable for: Adult
Purity: >99%
Molecular Weight: 499.61
Transport Package: Alunimum Foil Bag with Discreet Package
Origin: China
Powder: Yes
Certification: GMP, USP, BP
State: Solid
Molecular Form
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Description
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Quick Details:
 

AZD-9291 Mesylate
Synonyms:AZD-9291 (Mesylate);Osimertinib mesylate;Mereletinib mesylate;Osimertinib;N-[2-(2-dimethylaminoethylmethylamino)-4-methoxy-5-[[4-(1-methylindol-3-yl)pyrimidin-2-yl]amino]phenyl]prop-2-enamide mesylate salt
CAS: 1421373-66-1
MF:C28H33N7O2.CH4O3S
MW:0
Appearance:White to brown powder

COA:
 
 Items of analysis         Specification                Results
 Appearance       Yellow powder            Conforms
 Identification HPLC          Conforms
 Loss on drying ≤1.0% 0.18%
 Residue on ignition        ≤0.5%   0.10%
 Single impurity        ≤0.5%            0.07%
 Total impurity       ≤1.0%        0.26%
 Assay(HPLC) ≥99.0%        99.74%

Application:

AZD 9291 can be an irreversible inhibitor of epidermal growth factor receptor (EGFR) sensitizing and T790M resistance mutations (IC50s = 15-17 nM) while sparing the wild-type type of the receptor (IC50 = 480 nM). It binds the relatedis shown to inhibit tumor growth in a xenograft mouse model at oral doses of 5-10 mg/kg and it has been tested clinically in patients with advanced EGFR mutant non-small-cell united states.



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