Kinase Inhibitors Afatinib 439081-18-2 Gilotrif for Lung Cancer Treatment

Item No.: 439081-18-2
Model NO.: 439081-18-2
Customized: Non-Customized
Suitable for: Elderly, Children, Adult
Purity: >99%
MF: C24H25ClFN5O3
Certification: GMP, ISO 9001
Quality Standard: Bp, USP, Ep, Cp
HS Code: 3002200000
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USP Kinase Inhibitors Afatinib 439081-18-2 Gilotrif for Lung Cancer Treatment 

Quick Details:

 

Product name: Afatinib (BIBW 2992);Gilotrif
Synonyms: BIBW 2992;N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide;Tovok;Tovok, BIBW 2992;BIBW2992 Afatinib;Afatinib (BIBW 2992);ToMtovok;(S,E)-N-(4-(3-chloro-4-fluorophenylaMino)-7-(tetrahydrofuran-3-yloxy)quinazolin-6-yl)-4-(diMethylaMino)but-2-enaMide
CAS: 439081-18-2
MF: C24H25ClFN5O3
MW: 485.944
Purity: 99.5% min 
Appearance: White or Nearly White Crystalline Powder
MOQ: 10G
Specifications: Pharmaceutical Grade
Deliver time: About 5 days
Deliver methods: TNT,EMS,HKEMS,DHL,ect.(door to door)

 What is Afatinib ?

Afatinib is pronounced aff-a-tin-ib. It has the brand name Giotrif (jee-oh-triff). It is a type of biological therapy called a tyrosine kinase inhibitor (TKI). It is a treatment for non small cell lung cancer that has spread outside the lung or to other parts of the body.

It has received regulatory approval for use as a treatment for non-small cell lung cancer,although there is emerging evidence to support its use in other cancers such as breast cancer.

 How afatinib works:

This type of drug works by blocking particular proteins on cancer cells that encourage the cancer to grow. Afatinib blocks proteins called epidermal growth factor receptors (EGFR). Cancers that have these receptors are called EGFR positive.

Between 10 and 15 people out of every 100 with non small cell lung cancer (10 to 15%) have EGFR positive cancer. Doctors check your cancer cells to see if they have the receptors before you have this treatment.

Afatinib may shrink the cancer or stop it growing for a time

 Uses and fuction:

Afatinib is used to treat a certain type of lung cancer (non-small cell lung cancer) that has spread to other parts of the body. It belongs to a class of drugs known as kinase inhibitors. It works by slowing or stopping the growth of cancer cells. It binds to a certain protein (epidermal growth factor receptor-EGFR) in some tumors.

 Mechanism of action:

Like lapatinib and neratinib, afatinib is a protein kinase inhibitor that also irreversibly inhibits human epidermal growth factor receptor 2 (Her2) and epidermal growth factor receptor (EGFR) kinases. Afatinib is not only active against EGFR mutations targeted by first generation tyrosine-kinase inhibitors (TKIs) likeerlotinib or gefitinib, but also against mutations such as T790M which are not sensitive to these standard therapies.Because of its additional activity against Her2, it is being investigated for breast cancer as well as other EGFR and Her2 driven cancers.

COA:
 
Item Requirements Test Results
Description Off-white powder Off-white powder
Identification HPLC ,NMR Complies
Residue on Ignition ≤0.10% 0.05%
Loss on Drying ≤0.50% 0.15%
Heavy Metal ≤20ppm <20ppm
Purity(HPLC) ≥99.0% 99.99%
Conclusion It complies with EnterpriseStandard

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2. Full payment would be done once we come to an agreement on all details .
3. Parcel would be shipped out upon receipt of payment .
4. Info about parcel would be offered ( Photo , tracking number )
5. Finally you would get the parcel in 3~7 days .

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Injection Anabolic Steroid Hormone Drostanolone Enanthate/Masteron Enanthate
Our service:

1.We have experience in exporting Pharmaceutical intermediates .
2.Professional packing with professional materials
3. We have products in stock, and we will deliver them soon when your PO arrived. Meanwhile we will give you the tracking number in order to make you know the exact location of the products. We will keep track of the product until they arrive you; We choose the best courier service for you, and with the delivery around 5-7 working days.
If any new enquiry,please feel free to contact us!

Our Advantages:

1,High quality under strict QC/QA system with GMP factory price
2,Fast and safe delivery with secure and discreet shipment
3,Providing complete services with our resource integration, we can thus create more competitive
advantages for you!

 
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